Objectives: To examine how type I interferon (IFN-α) relates to vascular and neuronal abnormalities in systemic lupus erythematosus (SLE) and whether vascular dysfunction correlates with neuronal injury. Methods: In this cross‑sectional study of 147 …
OBJECTIVE: To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations. CSF samples from 29 female outpatients with SLE were analysed …
Using transgenic Drosophila models of Alzheimer’s disease, this study compared the effects of Tau and Amyloid‑β on behavioural function, autophagy gene expression and oxidative stress. Both aggregates induced behavioural deficits, autophagy gene …
Many computational predictors classify amino acid variants as either pathogenic or benign. PON‑P3 is an artificial intelligence‑based tool built on a large training dataset and 1,526 features describing variants, sequence and structural context and …
This population‑based study examined capillary leak syndrome (CLS) among children with multisystem inflammatory syndrome in children (MIS‑C) in Skåne, Sweden. Among 31 MIS‑C patients aged 0–18 years, CLS occurred in 45% and was present in all six …
Background: Modern rheumatology research increasingly involves large, complex datasets and requires methods beyond traditional univariate analyses. Objective: To highlight how transdisciplinary collaboration — integrating statisticians and data …
Background: Patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKi) have an increased risk of herpes zoster (HZ). A non‑live, recombinant subunit vaccine (Shingrix) offers protection in adults aged ≥50 years, but its …
OBJECTIVE: To determine if prior exposure to certain drugs is associated with increased risk of ANCA-associated vasculitis (AAV). This population‑based case–control study included 168 cases diagnosed with AAV between 2006 and 2019 and 1,763 matched …
Objective: Neuropsychiatric (NP) manifestations are common in systemic lupus erythematosus (SLE). Because cerebrospinal fluid (CSF) protein patterns may provide insight into NP pathogenesis, this study used a data‑driven approach to determine whether …
Background: Pulmonary manifestations contribute significantly to morbidity and mortality in rheumatoid arthritis (RA), yet biomarkers to identify patients at risk of lung involvement are lacking. Objective: To compare proteomic signatures in …