Using transgenic Drosophila models of Alzheimer’s disease, this study compared the effects of Tau and Amyloid‑β on behavioural function, autophagy gene expression and oxidative stress. Both aggregates induced behavioural deficits, autophagy gene …
Background: Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. …