Objectives: To examine how type I interferon (IFN-α) relates to vascular and neuronal abnormalities in systemic lupus erythematosus (SLE) and whether vascular dysfunction correlates with neuronal injury. Methods: In this cross‑sectional study of 147 …
Background: Modern rheumatology research increasingly involves large, complex datasets and requires methods beyond traditional univariate analyses. Objective: To highlight how transdisciplinary collaboration — integrating statisticians and data …
Background: Patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKi) have an increased risk of herpes zoster (HZ). A non‑live, recombinant subunit vaccine (Shingrix) offers protection in adults aged ≥50 years, but its …
OBJECTIVE: To determine if prior exposure to certain drugs is associated with increased risk of ANCA-associated vasculitis (AAV). This population‑based case–control study included 168 cases diagnosed with AAV between 2006 and 2019 and 1,763 matched …
Objective: Neuropsychiatric (NP) manifestations are common in systemic lupus erythematosus (SLE). Because cerebrospinal fluid (CSF) protein patterns may provide insight into NP pathogenesis, this study used a data‑driven approach to determine whether …
Background: Pulmonary manifestations contribute significantly to morbidity and mortality in rheumatoid arthritis (RA), yet biomarkers to identify patients at risk of lung involvement are lacking. Objective: To compare proteomic signatures in …
This conference abstract describes a directional probabilistic model to infer the orientational preferences of protein domains from small‑angle X‑ray scattering (SAXS) data. Two beads connected by a thread represent a flexible protein linker; the …