Proteomics

Data-Driven Cluster Analysis of Cerebrospinal Fluid Proteome and Associations with Clinical Phenotypes in Systemic Lupus Erythematosus

OBJECTIVE: To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations. CSF samples from 29 female outpatients with SLE were analysed …

Data-driven clustering of cerebrospinal fluid proteome reflects clinical phenotypes of systemic lupus erythematosus

Objective: Neuropsychiatric (NP) manifestations are common in systemic lupus erythematosus (SLE). Because cerebrospinal fluid (CSF) protein patterns may provide insight into NP pathogenesis, this study used a data‑driven approach to determine whether …

Proteomic signature in peripheral blood and sputum in rheumatoid arthritis patients with and without lung involvement

Background: Pulmonary manifestations contribute significantly to morbidity and mortality in rheumatoid arthritis (RA), yet biomarkers to identify patients at risk of lung involvement are lacking. Objective: To compare proteomic signatures in …