Systemic Lupus Erythematosus

Endothelial dysfunction, arterial stiffness, and neuronal injury in systemic lupus erythematosus: associations with type I interferon

Objectives: To examine how type I interferon (IFN-α) relates to vascular and neuronal abnormalities in systemic lupus erythematosus (SLE) and whether vascular dysfunction correlates with neuronal injury. Methods: In this cross‑sectional study of 147 …

Data-Driven Cluster Analysis of Cerebrospinal Fluid Proteome and Associations with Clinical Phenotypes in Systemic Lupus Erythematosus

We investigated how cerebrospinal-fluid protein patterns relate to clinical manifestations of systemic lupus erythematosus. Proteomic measurements from 29 patients passing quality control were analysed using patient clustering and protein-network analysis, then related to clinical and neurocognitive data. The analysis identified groups with distinct molecular and clinical profiles, including differences in renal involvement and indicators of neuronal injury. Protein modules provided a complementary view of the relationships between biological processes and disease manifestations. By combining proteomics, statistical learning and clinical interpretation, the study explores heterogeneity within lupus and generates hypotheses for further investigation; it does not establish a clinically validated prediction tool.

Data-driven clustering of cerebrospinal fluid proteome reflects clinical phenotypes of systemic lupus erythematosus

Objective: Neuropsychiatric (NP) manifestations are common in systemic lupus erythematosus (SLE). Because cerebrospinal fluid (CSF) protein patterns may provide insight into NP pathogenesis, this study used a data‑driven approach to determine whether …